Loss of epithelial polarity impacts organ development and function; it is also oncogenic. AMPK. a key sensor of metabolic stress stabilizes cell-cell junctions and maintains epithelial polarity; its activation by Metformin protects the epithelial barrier against stress and suppresses tumorigenesis. How AMPK protects the epithelium remains unknown. https://lampsusaes.shop/product-category/outdoor-accessory/